Release date: December 18, 2006
Accreditation Expired
Program Description
Recent developments in the treatment of rheumatoid arthritis include the approval of two new biologic agents (abatacept and rituximab), earlier initiation of treatment, and a move toward tight control of therapy with consistent monitoring of disease activity. Data from clinical trials of abatacept and rituximab in patients with rheumatoid arthritis suggest these agents are relatively effective and safe. Other studies suggest that early treatment and tight control have the potential to increase clinical benefits and improve outcomes for a greater percentage of patients. There is still much debate about how to integrate information from clinical trials into clinical practice. Questions remain about how these new agents will be used and their place in the current rheumatoid arthritis armamentarium, which treatment strategies optimize outcomes, and how to implement tight control in the clinical setting. Our panel of rheumatology experts discusses these issues within the context of recent clinical trial results and the implications for treating patients with rheumatoid arthritis.
Target Audience
The target audience for this activity includes rheumatologists and rheumatology fellows.
Educational Objectives
Upon completion of this activity, participants will be able to:
Explain the limitations of DMARD therapy and the importance of early treatment of RA and tight control
Describe the roles that B-cells and T-cells play in the pathophysiology of RA
Compare the mechanisms of action, efficacy, and safety profiles of newer RA therapeutic agents
The views and opinions expressed in this activity are those of the faculty. They do not reflect the views of Bristol-Myers Squibb Company, any other manufacturer of pharmaceuticals, Medical Education Resources, Inc., or Scinexa, LLC.
The recommendations made in this program are based upon a combination of randomized clinical trials, current guidelines, and the clinical practice experience of the participating panelists. Any medications, diagnostic procedures or treatments discussed by the panelists should not be utilized without evaluation of their patient's conditions. Participants are urged to consult the full prescribing information on any drug mentioned in this activity for recommended dosage, indications, contraindications, warnings, precautions, and adverse effects before prescribing any medication.
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Roy Fleischmann, MD
St. Paul University Hospital, Dallas
Clinical Professor of Medicine University of Texas
Southwestern Medical Center, Dallas
Faculty
Kathryn Hobbs, MD
Associate Clinical Professor of Medicine
University of Colorado Health Sciences Center
Administrative Director,
Clinical Trials Unit Denver Arthritis Clinic
Philip Mease, MD
Head, Seattle Rheumatology Associates
Chief, Rheumatology Clinical Research, Swedish Hospital Medical Center
Clinical Professor, University of Washington School of Medicine
Seattle, Washington
Alan J. Bridges, MD
Professor of Medicine
University of Wisconsin School of Medicine and Public Health
Senior Vice-Chair Department of Medicine
Madison, Wisconsin